effects of novel 2-alkylaminosubstituted dihydropyridines on rabbit jejunum

Authors

f hadizadeh from the department of medicinal chemistry, pharmacy faculty, mashhad university of medical sciences, p.o.box 91775-1365, mashhad, iran

bf anaraki-firooz the biotechnology &pharmaceutical sciences research center, postal code 9196773117, bu-ali square, mashhad, 1ran

sih taqavi the department of pharmacology,jinnah medical and dental college, karachi, pakistan

abstract

in order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2- alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized. rabbit jejunum was used to determine the relaxant or antagonistic activity of the test compounds. the test compounds (6c-e) inhibited the spontaneous contractile activity dose-dependently and completely, while high-k+ contracted tissues were relaxed partially.

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Journal title:
medical journal of islamic republic of iran

جلد ۱۸، شماره ۴، صفحات ۳۶۱-۳۶۴

Keywords
[ 2 , ' d i m e t h y l a m i n o ' , ' s u b s t i t u t e d d i h y d r o p y r i d i n e s ' , ' r a b b i t j e j u n u m ' , ' c a l c i u m c h a n n e l . ' ]

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